3-Isopropoxy-5-trifluoromethylphenylboronic acid
(3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acid
CAS: 1256345-44-4
Molecular Formula: C10H12BF3O3
3-Isopropoxy-5-trifluoromethylphenylboronic acid - Names and Identifiers
3-Isopropoxy-5-trifluoromethylphenylboronic acid - Physico-chemical Properties
| Molecular Formula | C10H12BF3O3 |
| Molar Mass | 248.01 |
| Storage Condition | Sealed in dry,2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD16660265 |
3-Isopropoxy-5-trifluoromethylphenylboronic acid - Introduction
(3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acid is an organoboron compound with the formula C12H14BF3O3. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White to light yellow solid.
-Melting point: approximately 70-72°C.
-Molecular weight: 272.05g/mol.
-Solubility: Soluble in organic solvents, such as dimethyl sulfoxide, dichloromethane, etc.
-Stability: Stable under dry conditions.
Use:
- (3-Isoproxy-5-(trifluoromethyl)-phenyl)boronic acid is an important reagent in organic synthesis and is commonly used in the synthesis of benzimidazoles, melting alkynes and nitriles.
-It can be used as a substrate and ligand for cross-coupling reactions, used for catalyst synthesis and directional construction of carbon-carbon bonds.
Preparation Method:
(3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acids are typically prepared by reaction of boric acid with the corresponding aromatic iodide. The specific steps are as follows:
1.3-isopropoxy-5-(trifluoromethyl) phenyl iodide was added to the boric acid solution along with sodium hydroxide.
2. Stir the reaction mixture at room temperature and control the pH within the range.
3. After the reaction is completed, the solvent is evaporated to obtain the target product.
Safety Information:
- (3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acid is irritating to the skin and eyes. Pay attention to protective measures when using it, such as wearing gloves and goggles.
-Avoid inhaling the vapor of the powder or solution, and operate in a well-ventilated place.
-Storage should be sealed and kept away from fire and oxidizing agents.
-In case of accidental inhalation or contact with skin and eyes, rinse immediately with water and seek medical assistance.
Nature:
-Appearance: White to light yellow solid.
-Melting point: approximately 70-72°C.
-Molecular weight: 272.05g/mol.
-Solubility: Soluble in organic solvents, such as dimethyl sulfoxide, dichloromethane, etc.
-Stability: Stable under dry conditions.
Use:
- (3-Isoproxy-5-(trifluoromethyl)-phenyl)boronic acid is an important reagent in organic synthesis and is commonly used in the synthesis of benzimidazoles, melting alkynes and nitriles.
-It can be used as a substrate and ligand for cross-coupling reactions, used for catalyst synthesis and directional construction of carbon-carbon bonds.
Preparation Method:
(3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acids are typically prepared by reaction of boric acid with the corresponding aromatic iodide. The specific steps are as follows:
1.3-isopropoxy-5-(trifluoromethyl) phenyl iodide was added to the boric acid solution along with sodium hydroxide.
2. Stir the reaction mixture at room temperature and control the pH within the range.
3. After the reaction is completed, the solvent is evaporated to obtain the target product.
Safety Information:
- (3-Isopropoxy-5-(trifluoromethyl)-phenyl)boronic acid is irritating to the skin and eyes. Pay attention to protective measures when using it, such as wearing gloves and goggles.
-Avoid inhaling the vapor of the powder or solution, and operate in a well-ventilated place.
-Storage should be sealed and kept away from fire and oxidizing agents.
-In case of accidental inhalation or contact with skin and eyes, rinse immediately with water and seek medical assistance.
Last Update：2024-04-10 22:29:15
